Egg donation /IVF DO – IVF with donor eggs
Description of treatment
If a woman cannot get pregnant using her own egg cells, donor eggs provided by an eligible, anonymous donor are fertilized by the sperm of the patient’s partner.
Egg donation is legal in the Czech Republic and it is subject to rigorous control by the state authorities. Egg donors are healthy women between 18 and 35 years of age. All egg donors undergo a thorough medical screening assessing their physical as well as psychological health condition. Genetic testing aimed at detecting/ruling out genetic disorders, as well as STD testing for the presence of sexually transmitted diseases ( HIV, hepatitis B and C, syphilis) form an integral part of the medical screening.
An eligible egg donor is selected by our doctors on the basis of the questionnaire you have filled out. You will receive all non-identifying information about the egg donor (age, appearance, blood type, interests etc…)
Egg donation is anonymous. According to the current legislation a child born as a result of egg donation has no rights to seek identifying information about the egg donor, even after the child has reached the age of 18.
Egg donors are compensated for their effort and accrued expenses relating to egg donation.
Treatment – step by step
1. Selection of a suitable egg donor
- First you will be asked to fill out the form (oocyte donor typing), where you will specify your requests regarding the donor’s appearance.
- We kindly ask you to provide us with your photo or, with your permission, we will take a photo of you at our center.
- It is important to mention the Rh factor of both you and your partner.
- We will look for a suitable egg donor according to your requests.
- You will be informed as soon as the suitable egg donor has been found.
- At our centre, egg donation program involves a sole-match cycle (a match of one donor to one recipient), which means that each recipient is assigned one donor.
2. Synchronization of donor’s and recipient’s cycles
- Your menstrual cycle will be synchronized with the donor’s cycle (in most cases using birth control pills) so as to prepare your uterine lining for embryo implantation.
- Your treatment cycle timeline and the preliminary date of embryo transfer will be determined.
3. Preparation of uterine lining (endometrium)
- In order for an embryo to successfully implant, the uterine lining (endometrium) has to be thick enough.
- On the first day of your period you will start taking pills containing female hormones – estrogens (Estrofem, Estrifam, Progynova…).
- 12. – 14. day of your menstrual cycle an ultrasound scan will be performed to measure the thickness of the uterine lining (endometrium). This can be done at our clinic or your OB/GYN.
- We will discuss the results of the scan by phone or e-mail.
- The date of the donor‘s egg retrieval will be determined.
- Your partner will come to the centre on the day of egg retrieval to provide a sperm sample. If we already have your partner‘s frozen sperm samples, the thawed (cryopreserved) samples will be used.
- On the day of donor’s egg retrieval you will start taking one more female hormone – gestagen (Utrogestan, Utrogest…).
- Embryo transfer will be carried out 2-5 days after fertilization.
- On the day of donor’s egg retrieval, the obtained donor eggs will be fertilized with your partner’s sperm.
- Fertilization is performed using the ICSI technique – by injecting a single sperm directly into the egg.
5. Embryo culture
- Following fertilization the embryos will begin to divide and grow.
- Embryos can be cultured in the laboratory up to 120 hours (Day 5), after that they must be transferred into the uterus or frozen.
- Depending on the number, development progress and quality of the embryos, the embryologist will determine the best time to carry out embryo transfer.
- The aim of this complex processs of embryo development assessment is to determine the most opportune moment for embryo transfer, ensuring the highest chance for pregnancy.
- An embryo at the most advanced stage of development before transfer is called a blastocyst (5 day old embryo, blastocyst transfer).
- Surplus high quality embryos will be frozen (cryopreservation).
6. Embryo transfer
- Embryo replacement into the uterine cavity (ET) is performed without anesthesia, using a thin flexible catheter (hose). The tip of the catheter is under ultrasound guidance for its more precise positioning inside the uterine cavity.
- Embryo transfer is a completely painless procedure.
- The embryos are injected into the uterine cavity with a small amount of liquid (culture medium).
- After the procedure you will remain lying down until you are released from the clinic (about 1 hour).
7. Precautions after embryo transfer
- It is advised to take rest for a few days after the transfer (no strenuous physical activity, hot tub baths and no intercourse are recommended) for 1-2 weeks.
- After 1-2 weeks you can go back to your normal lifestyle, but avoid strenuous physical activity.
- Take the prescribed medicines regularly as indicated in your discharge instructions.
8. Pregnancy test, medication intake and monitoring pregnancy
- 20 days after the transfer take a pregnancy test (using the first morning urine).
- If the pregnancy test is positive, book your ultrasound appointment (cca in 7-10 days) and continue to take your medications until the 12th week of pregnancy.
- After week 12 of pregnancy gradually discontinue the medications over 7-10 days.
- Standard prenatal screening and regular check-ups with your OB/GYN will follow right after.
- If the pregnancy test is negative, discontinue the use of all medications and after the end of your next period, contact us to start preparation for frozen embryo transfer or to discuss further treatment.